Significats de mtdna en anglès

The evidence linking OA to mtDNA is not compelling at present.

MtDNA deletion mutations were identified in skeletal muscles of all patients.

Conclusion: The mtDNA T16189C variant is associated with MS and its different clinical expressions.

Nuclear loci offer support for major geographic lineages that were first inferred from mtDNA.

In this paper we use cytonuclear disequilibria to test the neutrality of mtDNA markers.

Results: From baseline to month 6, arms A and B showed similar thymic output and mtDNA.

The mtDNA haplogroups of 185 individuals from Native American tribes in Northeast North America were determined.

In particular, we will focus on the approach of targeting engineered endonucleases to specifically cleave mutant mtDNA.

The presence of increased MtDNA and GnDNA damage in AD suggest dual cell death cascades in AD.

Mitochondria maintain and express their own genome, referred to as mtDNA, which is required for proper mitochondrial function.

In contrast to mtDNA, the migration rates at autosomal and Z-linked nuDNA loci were negligible or much lower.

We demonstrated that these mutations reduce MRPS34 protein levels and the synthesis of OXPHOS subunits encoded by mtDNA.

The mitochondrial DNA (mtDNA) control region is believed to play an important biological role in mtDNA replication.

Together, these approaches offer hope to prevent the transmission of mtDNA disease and potentially reduce the impact of mtDNA mutations.

In children with a hepatocerebral phenotype most patients presented with complex I deficiency and mtDNA-depletion, three of which carried POLG1-mutations.

These changes were accompanied by an increase in the expression of mtDNA-encoded genes in DCM versus no change in ICM.